منابع مشابه
The Bcl-2-regulated apoptotic pathway.
Apoptosis (programmed cell death) is required for the removal of infected, damaged or unwanted cells and its disrupted regulation is implicated in cancer, autoimmunity and degenerative disorders. At the molecular level, multiple signaling pathways converge on a family of cysteine proteases (caspases), which when activated cause cellular destruction by cleaving a range of vital cellular substrat...
متن کاملNew treatment strategies for multiple myeloma by targeting BCL-2 and the mevalonate pathway.
Insight into the mechanisms of primary or acquired drug resistance of (hematological) malignancies is critical for the development of new treatment strategies. This review will focus on Bcl-2 and the mevalonate pathway as targets for reversal of drug resistance in multiple myeloma. The Bcl-2 protein is highly expressed in myeloma patients and in vitro studies have shown its role in the regulati...
متن کاملTargeting Bcl-2 in CLL: cui bono?
ing this work to humans. First, we do not know whether the molar concentration of CD3 is similarly limiting for the expression of transgenic human TCRs. If CD3 is indeed limiting, then the enhanced expression and functionality we achieve by cotransfection of CD3 and TCRs may be accompanied by enhanced toxicity. Thus, enhanced expression may increase the risk of mispairing of endogenous and tran...
متن کاملTargeting the proapoptotic factor Bcl-2 in non-Hodgkin's lymphoma.
Bcl-2 functions as a key survival factor for lymphocytes and is highly expressed in a majority of non-Hodgkin's lymphomas. The ability of oblimersen sodium (Genasense, previously known as G3139) to target bcl-2 messenger RNA and decrease Bcl-2 protein levels has the potential to enhance the activity of cytotoxic chemotherapy. Pretreatment with oblimersen followed by cyclophosphamide (Cytoxan, N...
متن کاملTargeting Bcl-2-IP3 receptor interaction to reverse Bcl-2's inhibition of apoptotic calcium signals.
The antiapoptotic protein Bcl-2 inhibits Ca2+ release from the endoplasmic reticulum (ER). One proposed mechanism involves an interaction of Bcl-2 with the inositol 1,4,5-trisphosphate receptor (IP3R) Ca2+ channel localized with Bcl-2 on the ER. Here we document Bcl-2-IP3R interaction within cells by FRET and identify a Bcl-2 interacting region in the regulatory and coupling domain of the IP3R....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2014
ISSN: 0923-7534
DOI: 10.1093/annonc/mdu301.2